Hemospray hemostasis in bleeding diffusely ulcerated esophagus.

ABSTRACT:

Background and aims

Bleeding from diffuse esophageal ulcerations can be difficult to treat. Hemospray is a hemostatic powder, and its mechanism of hemostasis is thought to be through concentrating clotting factors and forming mechanical plugs on bleeding vessels.

Methods

The authors present 3 consecutive cases of diffusely ulcerated esophagus with clinically significant bleeding. The first 2 cases failed conventional hemostatic treatment including clipping and injection therapy. In the third case, Hemospray was used as the first-line monotherapy.

Results

Immediate hemostasis was achieved in all 3 patients, and they did not develop recurrent bleeding for more than 2 months.

Conclusions

The authors propose that Hemospray application should be considered as the first-line therapy in diffuse esophageal ulcerations with clinically significant bleeding, potentially reducing the need to repeat endoscopy. Once the Hemospray achieves hemostasis, it provides a cyto-protective barrier on the diffusely ulcerated mucosa against ongoing acid reflux, allowing the new tissue to grow more efficiently during the ulcer healing period.

SUBMITTER: Tang SJ 

PROVIDER: S-EPMC6408944 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature