Ontology highlight
ABSTRACT:
SUBMITTER: Kikani CK
PROVIDER: S-EPMC6408955 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Kikani Chintan K CK Verona Erik V EV Ryu Jiyoon J Shen Yanying Y Ye Qingqing Q Zheng Li L Qian Ziliang Z Sakaue Hiroshi H Nakamura Kyoko K Du Jie J Ji Qunsheng Q Ogawa Wataru W Sun Lu-Zhe LZ Dong Lily Q LQ Liu Feng F
Science signaling 20121106 249
Enhanced activation of phosphoinositide 3-kinase (PI3K) is a hallmark of many human tumors because it promotes cell proliferation and survival through several mechanisms. One of these mechanisms is the phosphorylation of the serine and threonine kinase Akt at the cytosolic side of the plasma membrane by phosphoinositide-dependent protein kinase 1 (PDK1), which is recruited and activated by binding to the phosphoinositides produced by PI3K. We previously demonstrated increased nuclear accumulatio ...[more]