Dataset Information

Retinal signs and risk of incident dementia in the Atherosclerosis Risk in Communities study.

ABSTRACT:

Introduction

The easily-imaged retinal microvasculature may reflect the brain microvasculature and therefore be related to dementia.

Methods

In a population-based study of 12,482 adults aged 50-73 years (22% African American), we estimated the relationship of retinal characteristics from fundus photography (1993-1995) with incident all-cause dementia (1993-1995 to 2011-2013) and with etiologic subtype of dementia/mild cognitive impairment (2011-13).

Results

A total of 1259 (10%) participants developed dementia over a mean 15.6 years. Moderate/severe (vs. no) retinopathy (hazard ratio [HR], 1.86; 95% confidence interval [CI]: 1.36-2.55) and central retinal arteriolar equivalent (narrowest quartile vs. widest three quartiles; HR, 1.26; 95% CI: 1.09-1.45) were associated with all-cause dementia. Results were qualitatively stronger (but not statistically significantly different) in participants with diabetes. Retinopathy was associated with a joint outcome of cerebrovascular-related, but not Alzheimer's disease-related, dementia/mild cognitive impairment (HR, 2.29; 95% CI: 1.24-4.23).

Discussion

Exploration of measures in the eye may provide surrogate indices of microvascular lesions relevant to dementia.

SUBMITTER: Deal JA

PROVIDER: S-EPMC6408967 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Publications

Retinal signs and risk of incident dementia in the Atherosclerosis Risk in Communities study.

Deal Jennifer A JA Sharrett A Richey AR Albert Marilyn M Bandeen-Roche Karen K Burgard Sheila S Thomas Sonia Davis SD Gottesman Rebecca F RF Knopman David D Mosley Thomas T Klein Barbara B Klein Ronald R

Alzheimer's & dementia : the journal of the Alzheimer's Association 20181112 3

<h4>Introduction</h4>The easily-imaged retinal microvasculature may reflect the brain microvasculature and therefore be related to dementia.<h4>Methods</h4>In a population-based study of 12,482 adults aged 50-73 years (22% African American), we estimated the relationship of retinal characteristics from fundus photography (1993-1995) with incident all-cause dementia (1993-1995 to 2011-2013) and with etiologic subtype of dementia/mild cognitive impairment (2011-13).<h4>Results</h4>A total of 1259 ...[more]

PMID: 30439332

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Dataset Information

Retinal signs and risk of incident dementia in the Atherosclerosis Risk in Communities study.

Introduction

Methods

Results

Discussion

Publications

Retinal signs and risk of incident dementia in the Atherosclerosis Risk in Communities study.

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