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Propensity for Intra-abdominal and Hepatic Adiposity Varies Among Ethnic Groups.

ABSTRACT: BACKGROUND & AIMS:We compared fat storage in the abdominal region among individuals from 5 different ethnic-racial groups to determine whether fat storage is associated with disparities observed in metabolic syndrome and other obesity-associated diseases. METHODS:We collected data from 1794 participants in the Multiethnic Cohort Study (60-77 years old; of African, European [white], Japanese, Latino, or Native Hawaiian ancestry) with body mass index values of 17.1-46.2 kg/m2. From May 2013 through April 2016, participants visited the study clinic to undergo body measurements, an interview, and a blood collection. Participants were evaluated by dual-energy x-ray absorptiometry and abdominal magnetic resonance imaging. Among ethnic groups, we compared adiposity of the trunk, intra-abdominal visceral cavity, and liver, adjusting for total fat mass; we evaluated the association of adult weight change with abdominal adiposity; and we examined the prevalence of metabolic syndrome mediated by abdominal adiposity. RESULTS:Relative amounts of trunk, visceral, and liver fat varied significantly with ethnicity-they were highest in Japanese Americans, lowest in African Americans, and intermediate in the other groups. Compared with African Americans, the mean visceral fat area was 45% and 73% greater in Japanese American men and women, respectively, and the mean measurements of liver fat were 61% and 122% greater in Japanese American men and women. The visceral and hepatic adiposity associated with weight gain since participants were 21 years old varied in a similar pattern among ethnic-racial groups. In the mediation analysis, visceral and liver fat jointly accounted for a statistically significant fraction of the difference in metabolic syndrome prevalence, compared with white persons, for African Americans, Japanese Americans, and Native Hawaiian women, independently of total fat mass. CONCLUSIONS:In an analysis of data from the participants in the Multiethnic Cohort Study, we found extensive differences among ethnic-racial groups in the propensity to store fat intra-abdominally. This observation should be considered by clinicians in the prevention and early detection of metabolic disorders.

SUBMITTER: Lim U

PROVIDER: S-EPMC6409195 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Propensity for Intra-abdominal and Hepatic Adiposity Varies Among Ethnic Groups.

Lim Unhee U Monroe Kristine R KR Buchthal Steve S Fan Bo B Cheng Iona I Kristal Bruce S BS Lampe Johanna W JW Hullar Meredith A MA Franke Adrian A AA Stram Daniel O DO Wilkens Lynne R LR Shepherd John J Ernst Thomas T Le Marchand Loïc L

Gastroenterology 20181113 4

<h4>Background & aims</h4>We compared fat storage in the abdominal region among individuals from 5 different ethnic-racial groups to determine whether fat storage is associated with disparities observed in metabolic syndrome and other obesity-associated diseases.<h4>Methods</h4>We collected data from 1794 participants in the Multiethnic Cohort Study (60-77 years old; of African, European [white], Japanese, Latino, or Native Hawaiian ancestry) with body mass index values of 17.1-46.2 kg/m<sup>2</ ...[more]

PMID: 30445012

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Propensity for Intra-abdominal and Hepatic Adiposity Varies Among Ethnic Groups.

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Propensity for Intra-abdominal and Hepatic Adiposity Varies Among Ethnic Groups.

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