Ontology highlight
ABSTRACT:
SUBMITTER: Liao R
PROVIDER: S-EPMC6409425 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Stem cell reports 20190207 3
The neurological recovery following traumatic brain injury (TBI) is limited, largely due to a deficiency in neurogenesis. The present study explores the effects of histamine H3 receptor (H3R) antagonism on TBI and mechanisms related to neurogenesis. H3R antagonism or H3R gene knockout alleviated neurological injury in the late phase of TBI, and also promoted neuroblast differentiation to enhance neurogenesis through activation of the histaminergic system. Histamine H1 receptor, but not H2 recept ...[more]