Unknown

Dataset Information

0

Lymphoid-Biased Hematopoietic Stem Cells Are Maintained with Age and Efficiently Generate Lymphoid Progeny.


ABSTRACT: Current models propose that reductions in the number of lymphoid-biased hematopoietic stem cells (Ly-HSCs) underlie age-related declines in lymphopoiesis. We show that Ly-HSCs do not decline in number with age. Old Ly-HSCs exhibit changes in gene expression and a myeloid-biased genetic profile, but we demonstrate that they retain normal lymphoid potential when removed from the old in vivo environment. Additional studies showing that interleukin-1 inhibits Ly-HSC lymphoid potential provide support for the hypothesis that increased production of inflammatory cytokines during aging underlies declines in lymphocyte production. These results indicate that current models proposing that lymphopoiesis declines with age due to loss of Ly-HSCs require revision and provide an additional perspective on why lymphocyte development in the elderly is attenuated.

SUBMITTER: Montecino-Rodriguez E 

PROVIDER: S-EPMC6409485 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Lymphoid-Biased Hematopoietic Stem Cells Are Maintained with Age and Efficiently Generate Lymphoid Progeny.

Montecino-Rodriguez Encarnacion E   Kong Ying Y   Casero David D   Rouault Adrien A   Dorshkind Kenneth K   Pioli Peter D PD  

Stem cell reports 20190221 3


Current models propose that reductions in the number of lymphoid-biased hematopoietic stem cells (Ly-HSCs) underlie age-related declines in lymphopoiesis. We show that Ly-HSCs do not decline in number with age. Old Ly-HSCs exhibit changes in gene expression and a myeloid-biased genetic profile, but we demonstrate that they retain normal lymphoid potential when removed from the old in vivo environment. Additional studies showing that interleukin-1 inhibits Ly-HSC lymphoid potential provide suppor  ...[more]

Similar Datasets

| S-EPMC3003003 | biostudies-literature
2019-02-21 | GSE112769 | GEO
| S-EPMC3003054 | biostudies-literature
2013-05-01 | E-GEOD-41702 | biostudies-arrayexpress
| S-EPMC3250139 | biostudies-literature
2013-05-01 | GSE41702 | GEO
| S-EPMC2475548 | biostudies-literature
| S-EPMC5886750 | biostudies-literature
| S-EPMC8996222 | biostudies-literature
| S-EPMC3347663 | biostudies-literature