Ontology highlight
ABSTRACT:
SUBMITTER: Jamison MT
PROVIDER: S-EPMC6410253 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Jamison Matthew T MT Wang Xiao X Cheng Tina T Molinski Tadeusz F TF
Marine drugs 20190207 2
Bengazoles A⁻G from the marine sponge <i>Jaspis</i> sp. exhibit potent in vitro antifungal activity against <i>Candida</i> spp. and other pathogenic fungi. The mechanism of action (MOA) of bengazole A was explored in <i>Candida albicans</i> under both liquid culture and surface culture on Mueller-Hinton agar. Pronounced dose-dependent synergistic antifungal activity was observed with bengazole A in the presence of bengamide A, which is also a natural product from <i>Jaspis</i> sp. The MOA of ben ...[more]