Ontology highlight
ABSTRACT:
SUBMITTER: Fleming E
PROVIDER: S-EPMC6410773 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Fleming Eleanor E Yuan Andy H AH Heller Danielle M DM Hochschild Ann A
Proceedings of the National Academy of Sciences of the United States of America 20190219 10
Prions are infectious, self-propagating protein aggregates that are notorious for causing devastating neurodegenerative diseases in mammals. Recent evidence supports the existence of prions in bacteria. However, the evaluation of candidate bacterial prion-forming proteins has been hampered by the lack of genetic assays for detecting their conversion to an aggregated prion conformation. Here we describe a bacteria<i>-</i>based genetic assay that distinguishes cells carrying a model yeast prion pr ...[more]