Ontology highlight
ABSTRACT:
SUBMITTER: Wang XH
PROVIDER: S-EPMC6410872 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20190215 10
Trimeric intracellular cation (TRIC) channels are thought to provide counter-ion currents that facilitate the active release of Ca<sup>2+</sup> from intracellular stores. TRIC activity is controlled by voltage and Ca<sup>2+</sup> modulation, but underlying mechanisms have remained unknown. Here we describe high-resolution crystal structures of vertebrate TRIC-A and TRIC-B channels, both in Ca<sup>2+</sup>-bound and Ca<sup>2+</sup>-free states, and we analyze conductance properties in structure-i ...[more]