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The related factors of sleep benefit in Parkinson's disease: A systematic review and meta-analysis.

ABSTRACT: BACKGROUND:Sleep benefit (SB) refers to the poorly understood phenomenon in Parkinson's disease (PD) in which patients wake up in the morning with improved motor function. Although previous studies have suggested that several related factors are associated with SB, this relationship remains controversial. OBJECTIVE:This systematic review and meta-analysis aimed to identify the possible related factors of SB in PD. METHODS:We searched PubMed, EMBASE and WanFang databases to collect eligible articles. We calculated pooled estimates of odds ratios (ORs) or the mean deviation (MD) with 95% confidence intervals. RESULTS:We found 3 related factors associated with SB: the duration of PD (MD 1.22, 95% CI: 0.21-2.23), sleep efficiency (MD -4.48,95% CI: -7.24- -2.44), and on-state MDS-UPDRS-? total score (MD 3.05, 95% CI: 0.53-5.57). CONCLUSION:PD patients with SB are more likely to have a long duration of PD, a low sleep efficiency and a high MDS-UPDRS-? total score. Our work helps obtain a better understanding of sleep SB in PD and its underlying mechanisms. More studies need to be conducted to evaluate the associations between clinical factors in PD and the SB phenomenon.

SUBMITTER: Rui Z

PROVIDER: S-EPMC6411108 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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The related factors of sleep benefit in Parkinson's disease: A systematic review and meta-analysis.

Rui Zhong Z Qingling Chen C Xinyue Zhang Z Xin Zhang Z Weihong Lin L

PloS one 20190311 3

<h4>Background</h4>Sleep benefit (SB) refers to the poorly understood phenomenon in Parkinson's disease (PD) in which patients wake up in the morning with improved motor function. Although previous studies have suggested that several related factors are associated with SB, this relationship remains controversial.<h4>Objective</h4>This systematic review and meta-analysis aimed to identify the possible related factors of SB in PD.<h4>Methods</h4>We searched PubMed, EMBASE and WanFang databases to ...[more]

PMID: 30856190

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Project description:ObjectiveTo assess the effectiveness of physiotherapy compared with no intervention in patients with Parkinson's disease.DesignSystematic review and meta-analysis of randomised controlled trials.Data sourcesLiterature databases, trial registries, journals, abstract books, and conference proceedings, and reference lists, searched up to the end of January 2012.Review methodsRandomised controlled trials comparing physiotherapy with no intervention in patients with Parkinson's disease were eligible. Two authors independently abstracted data from each trial. Standard meta-analysis methods were used to assess the effectiveness of physiotherapy compared with no intervention. Tests for heterogeneity were used to assess for differences in treatment effect across different physiotherapy interventions used. Outcome measures were gait, functional mobility and balance, falls, clinician rated impairment and disability measures, patient rated quality of life, adverse events, compliance, and economic analysis outcomes.Results39 trials of 1827 participants met the inclusion criteria, of which 29 trials provided data for the meta-analyses. Significant benefit from physiotherapy was reported for nine of 18 outcomes assessed. Outcomes which may be clinically significant were speed (0.04 m/s, 95% confidence interval 0.02 to 0.06, P<0.001), Berg balance scale (3.71 points, 2.30 to 5.11, P<0.001), and scores on the unified Parkinson's disease rating scale (total score -6.15 points, -8.57 to -3.73, P<0.001; activities of daily living subscore -1.36, -2.41 to -0.30, P=0.01; motor subscore -5.01, -6.30 to -3.72, P<0.001). Indirect comparisons of the different physiotherapy interventions found no evidence that the treatment effect differed across the interventions for any outcomes assessed, apart from motor subscores on the unified Parkinson's disease rating scale (in which one trial was found to be the cause of the heterogeneity).ConclusionsPhysiotherapy has short term benefits in Parkinson's disease. A wide range of physiotherapy techniques are currently used to treat Parkinson's disease, with little difference in treatment effects. Large, well designed, randomised controlled trials with improved methodology and reporting are needed to assess the efficacy and cost effectiveness of physiotherapy for treating Parkinson's disease in the longer term.

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The related factors of sleep benefit in Parkinson's disease: A systematic review and meta-analysis.

Publications

The related factors of sleep benefit in Parkinson's disease: A systematic review and meta-analysis.

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