Exploring the relationship between electrical impedance myography and quantitative ultrasound parameters in Duchenne muscular dystrophy.

ABSTRACT: OBJECTIVES:Quantitative ultrasound (QUS), including grayscale level analysis (GLA) and quantitative backscatter analysis (QBA), and electrical impedance myography (EIM) have been proposed as biomarkers in Duchenne muscular dystrophy (DMD). However, the relationship between these methods has not been assessed. METHODS:QUS values (including GLA and QBA) and several EIM measures were recorded from six muscles in 36 DMD and 29 healthy boys between ages 5 and 13?years at baseline, 6-months, and 12-months. RESULTS:In the DMD boys, a moderate correlation was noted between QUS and EIM parameters, with the strongest correlations being identified for averaged muscle values. Of the individual muscles, biceps brachii and deltoid showed the strongest correlations. For example, in biceps, the QBA/EIM correlation coefficient (Spearman rho) was ?0.70 (p?

SUBMITTER: Roy B 

PROVIDER: S-EPMC6411427 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature