Dataset Information

Neural response during emotion regulation in monozygotic twins at high familial risk of affective disorders.

ABSTRACT:

Purpose

We investigated the neural correlates of emotion regulation and -reactivity in adult unaffected monozygotic twins with a co-twin history of unipolar or bipolar disorder (high-risk), remitted or partially remitted twins with a personal history of unipolar or bipolar disorder (affected) and twins with no personal or first-degree family history of unipolar or bipolar disorder (low-risk).

Methods

We assessed 37 high-risk, 56 affected and 28 low-risk participants. Participants viewed unpleasant and neutral pictures during functional magnetic resonance imaging and were instructed to down-regulate their emotional response through reappraisal or mental imagery, as well as to maintain the elicited emotion.

Results

After adjusting for subsyndromal depressive symptoms, bilateral supplementary motor areas, posterior dorsal anterior cingulate cortices and the left frontal eye field showed less activity during reappraisal of unpleasant pictures in high-risk than low-risk participants. Notably, affected participants did not differ from high-risk or low-risk participants in neural response during reappraisal. There were no group differences in ventrolateral prefrontal cortex seed based functional connectivity during reappraisal or neural response during mental imagery or emotional reactivity.

Conclusion

Lesser response in dorsal midline areas might reflect familial risk related abnormalities during down regulation of emotional reactivity through reappraisal.

SUBMITTER: Meluken I

PROVIDER: S-EPMC6411590 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Neural response during emotion regulation in monozygotic twins at high familial risk of affective disorders.

Meluken Iselin I Ottesen Ninja Meinhard NM Phan K Luan KL Goldin Phillipe R PR Di Simplicio Martina M Macoveanu Julian J Siebner Hartwig Roman HR Kessing Lars Vedel LV Vinberg Maj M Miskowiak Kamilla Woznica KW

NeuroImage. Clinical 20181113

<h4>Purpose</h4>We investigated the neural correlates of emotion regulation and -reactivity in adult unaffected monozygotic twins with a co-twin history of unipolar or bipolar disorder (high-risk), remitted or partially remitted twins with a personal history of unipolar or bipolar disorder (affected) and twins with no personal or first-degree family history of unipolar or bipolar disorder (low-risk).<h4>Methods</h4>We assessed 37 high-risk, 56 affected and 28 low-risk participants. Participants ...[more]

PMID: 30527356

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Dataset Information

Neural response during emotion regulation in monozygotic twins at high familial risk of affective disorders.

Purpose

Methods

Results

Conclusion

Publications

Neural response during emotion regulation in monozygotic twins at high familial risk of affective disorders.

Similar Datasets

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