Dataset Information
Association of rs2234693 and rs9340799 polymorphisms of estrogen Receptor-1 gene with radiographic defined knee osteoarthritis: A meta-analysis.
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ABSTRACT: Objective
To evaluate the association of ESR1 rs2234693 and rs9340799 polymorphisms with radiographic defined knee osteoarthritis (OA), a case-control and meta-analysis was performed.Methods
A total of 25 case-control studies with 7,144 cases and 8,468 controls with were included.Results
There was a significant association between rs2234693 polymorphism and radiographic knee OA under heterozygote model (CT vs. TT: OR = 1.164, 95% CI 1.053-1.286, p = 0.003). However, there was no association between rs9340799 and radiographic knee OA. In subgroup analysis by ethnicity, risk estimates were not augmented.Conclusions
Our results showed that the ESR1 rs2234693 polymorphism might be associated with radiographic defined knee OA, but not rs9340799.
SUBMITTER: Ahrar H
PROVIDER: S-EPMC6411600 | biostudies-literature | 2019 May-Jun
REPOSITORIES: biostudies-literature
Publications
Association of rs2234693 and rs9340799 polymorphisms of estrogen Receptor-1 gene with radiographic defined knee osteoarthritis: A meta-analysis.
Journal of orthopaedics 20190228 3
<h4>Objective</h4>To evaluate the association of ESR1 rs2234693 and rs9340799 polymorphisms with radiographic defined knee osteoarthritis (OA), a case-control and meta-analysis was performed.<h4>Methods</h4>A total of 25 case-control studies with 7,144 cases and 8,468 controls with were included.<h4>Results</h4>There was a significant association between rs2234693 polymorphism and radiographic knee OA under heterozygote model (CT vs. TT: OR = 1.164, 95% CI 1.053-1.286, p = 0.003). However, there ...[more]