Recombinant platelet derived growth factor-BB and hyaluronic acid effect in rat osteoarthritis models.

ABSTRACT: Osteoarthritis (OA) arises from imbalance of cartilage metabolism between the synthesis and degradation of type II collagen by the chondrocyte. Collagen type II degradation is characterized by increase in the biomarker of C-telopeptide fragment of type II collagen (CTX-II), while the anabolic process of cartilage is characterized by an increase in the biosynthesis of procollagen amino terminal N-propeptide type IIA (PIIANP). Platelet derived growth factor (PDGF) with Hyaluronic Acid (HA) as a potent growth factor can be used to stimulate the higher formation of chondrocyte and PIIANP levels and lower CTX-II levels in mouse knee osteoarthritis model.

SUBMITTER: Setiawan IGNY 

PROVIDER: S-EPMC6411620 | biostudies-literature | 2019 May-Jun

REPOSITORIES: biostudies-literature