Ontology highlight
ABSTRACT:
SUBMITTER: de Queiroz RM
PROVIDER: S-EPMC6411693 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Frontiers in oncology 20190305
The Hexosamine Biosynthetic Pathway (HBP) is a branch of glycolysis responsible for the production of a key substrate for protein glycosylation, UDP-GlcNAc. Cancer cells present altered glucose metabolism and aberrant glycosylation, pointing to alterations on HBP. Recently it was demonstrated that HBP influences many aspects of tumor biology, including the development of metastasis. In this work we characterize HBP in melanoma cells and analyze its importance to cellular processes related to the ...[more]