Enzymatic origin and various curvatures of metabolic scaling in microbes.

ABSTRACT: The famous and controversial power law is a basal metabolic scaling model mainly derived from the "surface rule" or a fractal transport network. However, this law neglects biological mechanisms in the important active state. Here, we hypothesized that the relative metabolic rate and growth rate of actively growing microbes are driven by the changeable rate of their rate-limiting enzymes and concluded that natural logarithmic microbial metabolism (lnλ) and growth (or biomass) (lnM) are both dependent on limiting resources, and then developed novel models with interdependence between lnλ and lnM. We tested the models using the data obtained from the literature. We explain how and why the scaling is usually curved with the difference between microbial metabolic and growth (or biomass's) half-

SUBMITTER: Li L 

PROVIDER: S-EPMC6411939 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature