Ontology highlight
ABSTRACT:
SUBMITTER: Alho DPS
PROVIDER: S-EPMC6412232 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Alho Daniela P S DPS Salvador Jorge A R JAR Cascante Marta M Marin Silvia S
Molecules (Basel, Switzerland) 20190220 4
A new series of glycyrrhetinic acid derivatives has been synthesized via the introduction of different heterocyclic rings conjugated with an α,β-unsaturated ketone in its ring A. These new compounds were screened for their antiproliferative activity in a panel of nine human cancer cell lines. Compound <b>10</b> was the most active derivative, with an IC<sub>50</sub> of 1.1 µM on Jurkat cells, which is 96-fold more potent than that of glycyrrhetinic acid, and was 4-fold more selective toward that ...[more]