Ontology highlight
ABSTRACT:
SUBMITTER: Brown AK
PROVIDER: S-EPMC6412293 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Brown Alistair K AK Aljohani Ahmed K B AKB Gill Jason H JH Steel Patrick G PG Sellars Jonathan D JD
Molecules (Basel, Switzerland) 20190223 4
Discovery and development of new therapeutic options for the treatment of <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) infection are desperately needed to tackle the continuing global burden of this disease and the efficacy and cost limitations associated with current medicines. Herein, we report the synthesis of a series of novel benzoxa-[2,1,3]-diazole substituted amino acid hydrazides in a two-step synthesis and evaluate their inhibitory activity against <i>Mtb</i> and selected bacterial st ...[more]