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Antifungal Activity against Botrytis cinerea of 2,6-Dimethoxy-4-(phenylimino)cyclohexa-2,5-dienone Derivatives.


ABSTRACT: In this work the enzyme laccase from Trametes versicolor was used to synthetize 2,6-dimethoxy-4-(phenylimino)cyclohexa-2,5-dienone derivatives. Ten products with different substitutions in the aromatic ring were synthetized and characterized using ¹H- and 13C-NMR and mass spectrometry. The 3,5-dichlorinated compound showed highest antifungal activity against the phytopathogen Botrytis cinerea, while the p-methoxylated compound had the lowest activity; however, the antifungal activity of the products was higher than the activity of the substrates of the reactions. Finally, the results suggested that these compounds produced damage in the fungal cell wall.

SUBMITTER: Castro P 

PROVIDER: S-EPMC6412631 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Antifungal Activity against <i>Botrytis cinerea</i> of 2,6-Dimethoxy-4-(phenylimino)cyclohexa-2,5-dienone Derivatives.

Castro Paulo P   Mendoza Leonora L   Vásquez Claudio C   Pereira Paz Cornejo PC   Navarro Freddy F   Lizama Karin K   Santander Rocío R   Cotoras Milena M  

Molecules (Basel, Switzerland) 20190215 4


In this work the enzyme laccase from <i>Trametes versicolor</i> was used to synthetize 2,6-dimethoxy-4-(phenylimino)cyclohexa-2,5-dienone derivatives. Ten products with different substitutions in the aromatic ring were synthetized and characterized using ¹H- and <sup>13</sup>C-NMR and mass spectrometry. The 3,5-dichlorinated compound showed highest antifungal activity against the phytopathogen <i>Botrytis cinerea</i>, while the <i>p</i>-methoxylated compound had the lowest activity; however, the  ...[more]

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