Ontology highlight
ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC6412649 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Kim Jinhwan J Kim Yo-Han YH Bang Seunghyun S Yoo Hanju H Kim InKi I Chang Sung Eun SE Song Youngsup Y
Molecules (Basel, Switzerland) 20190221 4
Although melanin production is a key self-defense mechanism against ultraviolet radiation (UVR)-induced skin damage, uneven or excessive deposition of melanin causes hyperpigmentary disorders. Currently available whitening agents are unsatisfactory because of issues with efficacy and safety. To develop more effective depigmenting agents, we performed high-throughput melanin content assay screening using the B16F10 melanoma cell line and identified L-765,314 as a drug that suppressed melanin prod ...[more]