Unknown

Dataset Information

0

Antiplasmodial and Cytotoxic Cytochalasins from an Endophytic Fungus, Nemania sp. UM10M, Isolated from a Diseased Torreya taxifolia Leaf.

ABSTRACT: Bioassay-guided fractionation of an EtOAc extract of the broth of the endophytic fungus Nemania sp. UM10M (Xylariaceae) isolated from a diseased Torreya taxifolia leaf afforded three known cytochalasins, 19,20-epoxycytochalasins C (1) and D (2), and 18-deoxy-19,20-epoxy-cytochalasin C (3). All three compounds showed potent in vitro antiplasmodial activity and phytotoxicity with no cytotoxicity to Vero cells. These compounds exhibited moderate to weak cytotoxicity to some of the cell lines of a panel of solid tumor (SK-MEL, KB, BT-549, and SK-OV-3) and kidney epithelial cells (LLC-PK11). Evaluation of in vivo antimalarial activity of 19,20-epoxycytochalasin C (1) in a mouse model at 100 mg/kg dose showed that this compound had weak suppressive antiplasmodial activity and was toxic to animals.

SUBMITTER: Kumarihamy M 

PROVIDER: S-EPMC6413121 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Antiplasmodial and Cytotoxic Cytochalasins from an Endophytic Fungus, <i>Nemania</i> sp. UM10M, Isolated from a Diseased <i>Torreya taxifolia</i> Leaf.

Kumarihamy Mallika M   Ferreira Daneel D   Croom Edward M EM   Sahu Rajnish R   Tekwani Babu L BL   Duke Stephen O SO   Khan Shabana S   Techen Natascha N   Nanayakkara N P Dhammika NPD  

Molecules (Basel, Switzerland) 20190221 4

Bioassay-guided fractionation of an EtOAc extract of the broth of the endophytic fungus <i>Nemania</i> sp. UM10M (Xylariaceae) isolated from a diseased <i>Torreya taxifolia</i> leaf afforded three known cytochalasins, 19,20-epoxycytochalasins C (<b>1</b>) and D (<b>2</b>), and 18-deoxy-19,20-epoxy-cytochalasin C (<b>3</b>). All three compounds showed potent in vitro antiplasmodial activity and phytotoxicity with no cytotoxicity to Vero cells. These compounds exhibited moderate to weak cytotoxici  ...[more]

Similar Datasets

Unknown Pentacyclic Cytochalasins and Their Derivatives from the Endophytic Fungus Phomopsis sp. xz-18.
| S-EPMC8587572 | biostudies-literature
Unknown Antimalarials and Phytotoxins from Botryosphaeria dothidea Identified from a Seed of Diseased Torreya taxifolia.
| S-EPMC7795089 | biostudies-literature
Unknown Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818.
| S-EPMC6151419 | biostudies-other
Unknown New chlamydosporol derivatives from the endophytic fungus Pleosporales sp. Sigrf05 and their cytotoxic and antimicrobial activities.
| S-EPMC7234987 | biostudies-literature
Unknown Isochromophilones from an endophytic fungus Diaporthe sp.
| S-EPMC4131592 | biostudies-literature
Unknown Identification and Bioactivity of Compounds from the Mangrove Endophytic Fungus Alternaria sp.
| S-EPMC4515629 | biostudies-other
Unknown Secondary Metabolites from the Endophytic Fungus Xylaria sp. hg1009.
| S-EPMC5913051 | biostudies-literature
Transcriptomics Anti-inflammatory compounds from the mangrove endophytic fungus Amorosia sp. SCSIO 41026
2022-08-04 | GSE207442 | GEO
Unknown Cytotoxic metabolites from the endophytic fungus <i>Chaetomium globosum</i> 7951.
| S-EPMC9064350 | biostudies-literature
Unknown The newly isolated endophytic fungus Paraconiothyrium sp. LK1 produces ascotoxin.
| S-EPMC6268507 | biostudies-literature