Ontology highlight
ABSTRACT:
SUBMITTER: Okamura Y
PROVIDER: S-EPMC6413152 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Okamura Yoshihiko Y Makita Naoyuki N Hizukuri Yoshiyuki Y Hayashi Yasuhiro Y
Journal of clinical and experimental hematopathology : JCEH 20180413 2
Macrophages play a central role in the immune response, and their diverse functions are attributed to the spectrum of their functional states. To elucidate molecules involved in modulating the balance between the anti-inflammatory cytokine IL-10 and the pro-inflammatory cytokine TNF-α, we conducted genome-wide siRNA screening. First, we established an siRNA screening system using mouse bone marrow-derived macrophages, which are a suitable model for studying functional states of macrophages in vi ...[more]