Ontology highlight
ABSTRACT:
SUBMITTER: Mattei C
PROVIDER: S-EPMC6413170 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Mattei Cristiana C Lim Rebecca R Drury Hannah H Nasr Babak B Li Zihui Z Tadros Melissa A MA D'Abaco Giovanna M GM Stok Kathryn S KS Nayagam Bryony A BA Dottori Mirella M
Frontiers in cell and developmental biology 20190305
Hair cells are specialized mechanosensitive cells responsible for mediating balance and hearing within the inner ear. In mammals, hair cells are limited in number and do not regenerate. Human pluripotent stem cells (hPSCs) provide a valuable source for deriving human hair cells to study their development and design therapies to treat and/or prevent their degeneration. In this study we used a dynamic 3D Rotary Cell Culture System (RCCS) for deriving inner ear organoids from hPSCs. We show RCCS-de ...[more]