7T MRI allows detection of disturbed cortical lamination of the medial temporal lobe in patients with Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Kenkhuis B
PROVIDER: S-EPMC6413344 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
7T MRI allows detection of disturbed cortical lamination of the medial temporal lobe in patients with Alzheimer's disease.
Kenkhuis Boyd B Jonkman Laura E LE Bulk Marjolein M Buijs Mathijs M Boon Baayla D C BDC Bouwman Femke H FH Geurts Jeroen J G JJG van de Berg Wilma D J WDJ van der Weerd Louise L
NeuroImage. Clinical 20190105
Using 7T T2<sup>⁎</sup>-weighted imaging, we scanned post-mortem hemispheres of Alzheimer patients and age-matched controls to describe the patterns of appearance of cortical lamination on T2*-weighted MRI in the medial temporal lobe and to assess the changes in Alzheimer patients versus controls. While controls showed a hypointense line of Baillarger in the majority of the cases, appearance of cortical lamination varied to a greater extent in the Alzheimer patients. Severely distorted cortical ...[more]
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