Alogliptin improves survival and health of mice on a high-fat diet.
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ABSTRACT:
SUBMITTER: Zhu B
PROVIDER: S-EPMC6413659 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
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Alogliptin improves survival and health of mice on a high-fat diet.
Zhu Biao B Li Yixiang Y Xiang Lingwei L Zhang Jiajia J Wang Li L Guo Bei B Liang Minglu M Chen Long L Xiang Lin L Dong Jing J Liu Min M Mei Wen W Li Huan H Xiang Guangda G
Aging cell 20190115 2
Alogliptin is a commonly prescribed drug treating patients with type 2 diabetes. Here, we show that long-term intervention with alogliptin (0.03% w/w in diet) improves survival and health of mice on a high-fat diet. Alogliptin intervention takes beneficial effects associated with longevity, including increased insulin sensitivity, attenuated functionality decline, decreased organ pathology, preserved mitochondrial function, and reduced oxidative stress. Autophagy activation is proposed as an und ...[more]
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