SFRP3 inhibition improves age-related cellular changes in BubR1 progeroid mice.
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ABSTRACT:
SUBMITTER: Cho CH
PROVIDER: S-EPMC6413750 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
sFRP3 inhibition improves age-related cellular changes in BubR1 progeroid mice.
Cho Chang Hoon CH Yoo Ki Hyun KH Oliveros Alfredo A Paulson Summer S Hussaini Syed Mohammed Qasim SMQ van Deursen Jan M JM Jang Mi-Hyeon MH
Aging cell 20190104 2
Wnt signaling is a well-known molecular pathway in age-related pathogenesis and therapy of disease. While prior studies have mainly focused on Wnt ligands or Wnt activators, the in vivo functions of naturally secreted Wnt inhibitors are not clear, especially in brain aging. Using BubR1<sup>H/H</sup> mice as a novel mouse model of accelerated aging, we report that genetic inhibition of sFRP3 restores the reduced body and brain size observed in BubR1<sup>H/H</sup> mice. Furthermore, sFRP3 inhibiti ...[more]
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