Ontology highlight
ABSTRACT:
SUBMITTER: Bhowmick M
PROVIDER: S-EPMC6413923 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Bhowmick Manishabrata M Tokmina-Roszyk Dorota D Onwuha-Ekpete Lillian L Harmon Kelli K Robichaud Trista T Fuerst Rita R Stawikowska Roma R Steffensen Bjorn B Roush William W Wong Hector R HR Fields Gregg B GB
Journal of medicinal chemistry 20170419 9
The design of selective matrix metalloproteinase (MMP) inhibitors that also possess favorable solubility properties has proved to be especially challenging. A prior approach using collagen-model templates combined with transition state analogs produced a first generation of triple-helical peptide inhibitors (THPIs) that were effective in vitro against discrete members of the MMP family. These THPI constructs were also highly water-soluble. The present study sought improvements in the first gener ...[more]