Ontology highlight
ABSTRACT:
SUBMITTER: Wang G
PROVIDER: S-EPMC6414065 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Wang Guihua G Long Jie J Gao Yuan Y Zhang Weina W Han Fei F Xu Chuan C Sun Li L Yang Shun-Chin SC Lan Jingqin J Hou Zhenlin Z Cai Zhen Z Jin Guoxiang G Hsu Che-Chia CC Wang Yu-Hui YH Hu Junbo J Chen Tsai-Yu TY Li Hongyu H Lee Min Gyu MG Lin Hui-Kuan HK
Nature cell biology 20190128 2
The serine/threonine kinase Akt plays a central role in cell proliferation, survival and metabolism, and its hyperactivation is linked to cancer progression. Here we report that Akt undergoes K64 methylation by SETDB1, which is crucial for cell membrane recruitment, phosphorylation and activation of Akt following growth factor stimulation. Furthermore, we reveal an adaptor function of histone demethylase JMJD2A, which is important for recognizing Akt K64 methylation and recruits E3 ligase TRAF6 ...[more]