Ontology highlight
ABSTRACT:
SUBMITTER: Kumar AA
PROVIDER: S-EPMC6414077 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Kumar Anupam A AA Kelly Daniel P DP Chirinos Julio A JA
Circulation 20190301 11
Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with an increasingly recognized heterogeneity in pathophysiology. Exercise intolerance is the hallmark of HFpEF and appears to be caused by both cardiac and peripheral abnormalities in the arterial tree and skeletal muscle. Mitochondrial abnormalities can significantly contribute to impaired oxygen utilization and the resulting exercise intolerance in HFpEF. We review key aspects of the complex biology of this organelle ...[more]