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Use of high-resolution metabolomics for the identification of metabolic signals associated with traffic-related air pollution.


ABSTRACT: BACKGROUND:High-resolution metabolomics (HRM) is emerging as a sensitive tool for measuring environmental exposures and biological responses. The aim of this analysis is to assess the ability of high-resolution metabolomics (HRM) to reflect internal exposures to complex traffic-related air pollution mixtures. METHODS:We used untargeted HRM profiling to characterize plasma and saliva collected from participants in the Dorm Room Inhalation to Vehicle Emission (DRIVE) study to identify metabolic pathways associated with traffic emission exposures. We measured a suite of traffic-related pollutants at multiple ambient and indoor sites at varying distances from a major highway artery for 12?weeks in 2014. In parallel, 54 students living in dormitories near (20?m) or far (1.4?km) from the highway contributed plasma and saliva samples. Untargeted HRM profiling was completed for both plasma and saliva samples; metabolite and metabolic pathway alternations were evaluated using a metabolome-wide association study (MWAS) framework with pathway analyses. RESULTS:Weekly levels of traffic pollutants were significantly higher at the near dorm when compared to the far dorm (p?

SUBMITTER: Liang D 

PROVIDER: S-EPMC6414207 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Use of high-resolution metabolomics for the identification of metabolic signals associated with traffic-related air pollution.

Liang Donghai D   Moutinho Jennifer L JL   Golan Rachel R   Yu Tianwei T   Ladva Chandresh N CN   Niedzwiecki Megan M   Walker Douglas I DI   Sarnat Stefanie Ebelt SE   Chang Howard H HH   Greenwald Roby R   Jones Dean P DP   Russell Armistead G AG   Sarnat Jeremy A JA  

Environment international 20180807


<h4>Background</h4>High-resolution metabolomics (HRM) is emerging as a sensitive tool for measuring environmental exposures and biological responses. The aim of this analysis is to assess the ability of high-resolution metabolomics (HRM) to reflect internal exposures to complex traffic-related air pollution mixtures.<h4>Methods</h4>We used untargeted HRM profiling to characterize plasma and saliva collected from participants in the Dorm Room Inhalation to Vehicle Emission (DRIVE) study to identi  ...[more]

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