Ontology highlight
ABSTRACT:
SUBMITTER: van der Kant R
PROVIDER: S-EPMC6414424 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
van der Kant Rik R Langness Vanessa F VF Herrera Cheryl M CM Williams Daniel A DA Fong Lauren K LK Leestemaker Yves Y Steenvoorden Evelyne E Rynearson Kevin D KD Brouwers Jos F JF Helms J Bernd JB Ovaa Huib H Giera Martin M Wagner Steven L SL Bang Anne G AG Goldstein Lawrence S B LSB
Cell stem cell 20190124 3
Genetic, epidemiologic, and biochemical evidence suggests that predisposition to Alzheimer's disease (AD) may arise from altered cholesterol metabolism, although the molecular pathways that may link cholesterol to AD phenotypes are only partially understood. Here, we perform a phenotypic screen for pTau accumulation in AD-patient iPSC-derived neurons and identify cholesteryl esters (CE), the storage product of excess cholesterol, as upstream regulators of Tau early during AD development. Using i ...[more]