Ontology highlight
ABSTRACT:
SUBMITTER: Oostenbrink LVE
PROVIDER: S-EPMC6414431 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Oostenbrink Lisa V E LVE Jol-van der Zijde Cornelia M CM Kielsen Katrine K Jansen-Hoogendijk Anja M AM Ifversen Marianne M Müller Klaus G KG Lankester Arjan C AC van Halteren Astrid G S AGS Bredius Robbert G M RGM Schilham Marco W MW van Tol Maarten J D MJD
Frontiers in immunology 20190306
Anti-thymocyte globulin (ATG) is a lymphocyte depleting agent applied in hematopoietic stem cell transplantation (HSCT) to prevent rejection and Graft-vs.-Host Disease (GvHD). In this study, we compared two rabbit ATG products, ATG-Genzyme (ATG-GENZ), and ATG-Fresenius (ATG-FRES), with respect to dosing, clearance of the active lymphocyte binding component, post-HSCT immune reconstitution and clinical outcome. Fifty-eigth pediatric acute leukemia patients (<i>n</i> = 42 ATG-GENZ, <i>n</i> = 16 A ...[more]