Ontology highlight
ABSTRACT:
SUBMITTER: Lynch DR
PROVIDER: S-EPMC6414489 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Annals of clinical and translational neurology 20190227 3
<h4>Objective</h4>In vitro, in vivo, and open-label studies suggest that interferon gamma (IFN-<i>γ</i> 1b) may improve clinical features in Friedreich Ataxia through an increase in frataxin levels. The present study evaluates the efficacy and safety of IFN-<i>γ</i> 1b in the treatment of Friedreich Ataxia through a double-blind, multicenter, placebo-controlled trial.<h4>Methods</h4>Ninety-two subjects with FRDA between 10 and 25 years of age were enrolled. Subjects received either IFN-<i>γ</i> ...[more]