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Antibacterial activity of ovatodiolide isolated from Anisomeles indica against Helicobacter pylori.


ABSTRACT: Helicobacter pylori infection is associated with high incidence of gastric diseases. The extensive therapy of H. pylori infection with antibiotics has increased its resistance rates worldwide. Ovatodiolide, a pure constituent isolated from Anisomeles indica, has been demonstrated to possess bactericidal activity against H. pylori. In this study, ovatodiolide inhibited the growth of both H. pylori reference strain and clinical multidrug-resistant isolates. Docking analysis revealed that ovatodiolide fits into the hydrophobic pocket of a ribosomal protein, RpsB. Furthermore, ovatodiolide inhibited bacterial growth by reducing levels of RpsB, which plays a crucial role in protein translation. Our results demonstrate that ovatodiolide binds to a ribosomal protein and interferes with protein synthesis. This study provides evidence that ovatodiolide has the potential to be developed into a potent therapeutic agent for treating H. pylori infection.

SUBMITTER: Lien HM 

PROVIDER: S-EPMC6414523 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Antibacterial activity of ovatodiolide isolated from Anisomeles indica against Helicobacter pylori.

Lien Hsiu-Man HM   Wu Hui-Yu HY   Hung Chiu-Lien CL   Chen Chih-Jung CJ   Wu Chia-Lin CL   Chen Kuan-Wen KW   Huang Chao-Lu CL   Chang Sheau-Jiun SJ   Chen Chia-Chang CC   Lin Hwai-Jeng HJ   Lai Chih-Ho CH  

Scientific reports 20190312 1


Helicobacter pylori infection is associated with high incidence of gastric diseases. The extensive therapy of H. pylori infection with antibiotics has increased its resistance rates worldwide. Ovatodiolide, a pure constituent isolated from Anisomeles indica, has been demonstrated to possess bactericidal activity against H. pylori. In this study, ovatodiolide inhibited the growth of both H. pylori reference strain and clinical multidrug-resistant isolates. Docking analysis revealed that ovatodiol  ...[more]

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