Ontology highlight
ABSTRACT:
SUBMITTER: Cotero V
PROVIDER: S-EPMC6414607 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Nature communications 20190312 1
Tools for noninvasively modulating neural signaling in peripheral organs will advance the study of nerves and their effect on homeostasis and disease. Herein, we demonstrate a noninvasive method to modulate specific signaling pathways within organs using ultrasound (U/S). U/S is first applied to spleen to modulate the cholinergic anti-inflammatory pathway (CAP), and US stimulation is shown to reduce cytokine response to endotoxin to the same levels as implant-based vagus nerve stimulation (VNS). ...[more]