Browse
Submit Data
Databases
API
Help

Dataset Information

14 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Tumbling-Snake Model for Polymeric Liquids Subjected to Biaxial Elongational Flows with a Focus on Planar Elongation.

ABSTRACT: We have recently solved the tumbling-snake model for concentrated polymer solutions and entangled melts in the presence of both steady-state and transient shear and uniaxial elongational flows, supplemented by a variable link tension coefficient. Here, we provide the transient and stationary solutions of the tumbling-snake model under biaxial elongation both analytically, for small and large elongation rates, and via Brownian dynamics simulations, for the case of planar elongational flow over a wide range of rates, times, and the model parameters. We show that both the steady-state and transient first planar viscosity predictions are similar to their uniaxial counterparts, in accord with recent experimental data. The second planar viscosity seems to behave in all aspects similarly to the shear viscosity, if shear rate is replaced by elongation rate.

SUBMITTER: Stephanou PS

PROVIDER: S-EPMC6415193 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Tumbling-Snake Model for Polymeric Liquids Subjected to Biaxial Elongational Flows with a Focus on Planar Elongation.

Stephanou Pavlos S PS Kröger Martin M

Polymers 20180316 3

We have recently solved the tumbling-snake model for concentrated polymer solutions and entangled melts in the presence of both steady-state and transient shear and uniaxial elongational flows, supplemented by a variable link tension coefficient. Here, we provide the transient and stationary solutions of the tumbling-snake model under biaxial elongation both analytically, for small and large elongation rates, and via Brownian dynamics simulations, for the case of planar elongational flow over a ...[more]

PMID: 30966364

Similar Datasets

Running and tumbling with E. coli in polymeric solutions.

Project description:Run-and-tumble motility is widely used by swimming microorganisms including numerous prokaryotic and eukaryotic organisms. Here, we experimentally investigate the run-and-tumble dynamics of the bacterium E. coli in polymeric solutions. We find that even small amounts of polymer in solution can drastically change E. coli dynamics: cells tumble less and their velocity increases, leading to an enhancement in cell translational diffusion and a sharp decline in rotational diffusion. We show that suppression of tumbling is due to fluid viscosity while the enhancement in swimming speed is mainly due to fluid elasticity. Visualization of single fluorescently labeled DNA polymers reveals that the flow generated by individual E. coli is sufficiently strong to stretch polymer molecules and induce elastic stresses in the fluid, which in turn can act on the cell in such a way to enhance its transport. Our results show that the transport and spread of chemotactic cells can be independently modified and controlled by the fluid material properties.

| S-EPMC4938119 | biostudies-literature

Elastic instabilities in planar elongational flow of monodisperse polymer solutions.

Project description:We investigate purely elastic flow instabilities in the almost ideal planar stagnation point elongational flow field generated by a microfluidic optimized-shape cross-slot extensional rheometer (OSCER). We use time-resolved flow velocimetry and full-field birefringence microscopy to study the behavior of a series of well-characterized viscoelastic polymer solutions under conditions of low fluid inertia and over a wide range of imposed deformation rates. At low deformation rates the flow is steady and symmetric and appears Newtonian-like, while at high deformation rates we observe the onset of a flow asymmetry resembling the purely elastic instabilities reported in standard-shaped cross-slot devices. However, for intermediate rates, we observe a new type of elastic instability characterized by a lateral displacement and time-dependent motion of the stagnation point. At the onset of this new instability, we evaluate a well-known dimensionless criterion M that predicts the onset of elastic instabilities based on geometric and rheological scaling parameters. The criterion yields maximum values of M which compare well with critical values of M for the onset of elastic instabilities in viscometric torsional flows. We conclude that the same mechanism of tension acting along curved streamlines governs the onset of elastic instabilities in both extensional (irrotational) and torsional (rotational) viscoelastic flows.

| S-EPMC5018825 | biostudies-other

X-ray rheography uncovers planar granular flows despite non-planar walls.

Project description:Extremely useful techniques exist to observe the interior of deforming opaque materials, but these methods either require that the sample is replaced with a model material or that the motion is stopped intermittently. For example, X-ray computed tomography cannot measure the continuous flow of materials due to the significant scanning time required for density reconstruction. Here we resolve this technological gap with an alternative X-ray method that does not require such tomographs. Instead our approach uses correlation analysis of successive high-speed radiographs from just three directions to directly reconstruct three-dimensional velocities. When demonstrated on a steady granular system, we discover a compressible flow field that has planar streamlines despite curved confining boundaries, in surprising contrast to Newtonian fluids. More generally, our new X-ray technique can be applied using synchronous source/detector pairs to investigate transient phenomena in various soft matter such as biological tissues, geomaterials and foams.

| S-EPMC6269474 | biostudies-literature

MTOR-independent induction of autophagy in trabecular meshwork cells subjected to biaxial stretch.

Project description:The trabecular meshwork (TM) is part of a complex tissue that controls the exit of aqueous humor from the anterior chamber of the eye, and therefore helps maintaining intraocular pressure (IOP). Because of variations in IOP with changing pressure gradients and fluid movement, the TM and its contained cells undergo morphological deformations, resulting in distention and stretching. It is therefore essential for TM cells to continuously detect and respond to these mechanical forces and adapt their physiology to maintain proper cellular function and protect against mechanical injury. Here we demonstrate the activation of autophagy, a pro-survival pathway responsible for the degradation of long-lived proteins and organelles, in TM cells when subjected to biaxial static stretch (20% elongation), as well as in high-pressure perfused eyes (30mmHg). Morphological and biochemical markers for autophagy found in the stretched cells include elevated LC3-II levels, increased autophagic flux, and the presence of autophagic figures in electron micrographs. Furthermore, our results indicate that the stretch-induced autophagy in TM cells occurs in an MTOR- and BAG3-independent manner. We hypothesize that activation of autophagy is part of the physiological response that allows TM cells to cope and adapt to mechanical forces.

| S-EPMC3988584 | biostudies-literature

Survival of polymeric microstructures subjected to interrogatory touch.

Project description:Polymeric arrays of microrelief structures have a range of potential applications. For example, to influence wettability, to act as biologically inspired adhesives, to resist biofouling, and to play a role in the "feel" of an object during tactile interaction. Here, we investigate the damage to micropillar arrays comprising pillars of different modulus, spacing, diameter, and aspect ratio due to the sliding of a silicone cast of a human finger. The goal is to determine the effect of these parameters on the types of damage observed, including adhesive failure and ploughing of material from the finger onto the array. Our experiments point to four principal conclusions [1]. Aspect ratio is the dominant parameter in determining survivability through its effect on the bending stiffness of micropillars [2]. All else equal, micropillars with larger diameter are less susceptible to breakage and collapse [3]. The spacing of pillars in the array largely determines which type of adhesive failure occurs in non-surviving arrays [4]. Elastic modulus plays an important role in survivability. Clear evidence of elastic recovery was seen in the more flexible polymer and this recovery led to more instances of pristine survivability where the stiffer polymer tended to ablate PDMS. We developed a simple model to describe the observed bending of micropillars, based on the quasi-static mechanics of beam-columns, that indicated they experience forces ranging from 10-4-10-7 N to deflect into adhesive contact. Taken together, results obtained using our framework should inform design considerations for microstructures intended to be handled by human users.

| S-EPMC8412302 | biostudies-literature

Planar biaxial extension of the lumbar facet capsular ligament reveals significant in-plane shear forces.

Project description:The lumbar facet capsular ligament (FCL) articulates with six degrees of freedom during spinal motions of flexion/extension, lateral bending, and axial rotation. The lumbar FCL is composed of highly aligned collagen fiber bundles on the posterior surface (oriented primarily laterally between the rigid articular facets) and irregularly oriented elastin on the anterior surface. Because the FCL is a capsule, it has multiple insertion sites across the lumbar facet joint, which, along with its material structure, give rise to complicated deformations in vivo. We performed planar equibiaxial mechanical tests on excised healthy cadaveric lumbar FCLs (n=6) to extract normal and shear reaction forces, and fit sample-specific two-fiber-family finite element models to the experimental force data. An eight-parameter anisotropic, hyperelastic model was used. Shear forces at maximum extension (mean values of 1.68N and 3.01N in the two directions) were of comparable magnitude to the normal forces perpendicular to the aligned collagen fiber bundles (4.67N) but smaller than normal forces in the fiber direction (16.11N). Inclusion of the experimental shear forces in the model optimization yielded fits with highly aligned fibers oriented at a specific angle across all samples, typically with one fiber population aligned nearly horizontally and the other at an oblique angle. Conversely, models fit to only the normal force data resulted in a broad range of fiber angles with low specificity. We found that shear forces generated through planar equibiaxial extension aided the model fit in describing the anisotropic nature of the FCL surface.

| S-EPMC5154816 | biostudies-literature

Mechanical properties and progressive failure characteristics of sandstone containing elliptical and square openings subjected to biaxial stress.

Project description:Two kinds of common tunnel shapes, i.e. elliptical opening and square opening were selected for biaxial compression tests, and the influences of two kinds of opening shapes on the mechanical properties, failure characteristics and failure modes of sandstone were compared and analyzed. The complex variable theory and mapping functions were used to obtain the analytical stress solution around elliptical and square openings. The results show that the stability of the specimen containing an elliptical opening was better than that of the specimen containing a square opening under the same lateral stress. Compared with the elliptical opening, the local damage was formed earlier in the square opening which might be caused by a higher stress concentration around the square opening. The stress distributions around openings were influenced by the opening shape and lateral stress coefficient. The top and bottom of square opening were more prone to tensile fracture, and the distribution range of tensile was larger than that of elliptical opening. When the opening failed, the intensity of square opening failure was weaker than that of elliptical opening. On the basis of the average frequency value and the rise angle value, the failure mode of specimen containing elliptical or square opening was distinguished. It was found that the mixed tension and shear failure dominated the failure of specimens with different opening shapes, and the number of shear cracks in the specimen containing a square opening was greater than that in the specimen containing an elliptical opening. The above method of judging failure mode by acoustic emission signals was well verified by the CT images of damaged specimens.

| S-EPMC7932157 | biostudies-literature

Elongation and migration of single DNA molecules in microchannels using oscillatory shear flows.

Project description:Much of modern biology relies on the strategic manipulation of molecules for creating ordered arrays prior to high throughput molecular analysis. Normally, DNA arrays involve deposition on surfaces, or confinement in nanochannels; however, we show that microfluidic devices can present stretched molecules within a controlled flow in ways complementing surface modalities, or extreme confinement conditions. Here we utilize pressure-driven oscillatory shear flows generated in microchannels as a new way of stretching DNA molecules for imaging "arrays" of individual DNA molecules. Fluid shear effects both stretch DNA molecules and cause them to migrate away from the walls becoming focused in the centerline of a channel. We show experimental findings confirming simulations using Brownian dynamics accounting for hydrodynamic interactions between molecules and channel-flow boundary conditions. Our findings characterize DNA elongation and migration phenomena as a function of molecular size, shear rate, oscillatory frequency with comparisons to computer simulation studies.

| S-EPMC2768593 | biostudies-literature

Mechanical control of tissue shape and morphogenetic flows during vertebrate body axis elongation.

Project description:Shaping embryonic tissues into their functional morphologies requires cells to control the physical state of the tissue in space and time. While regional variations in cellular forces or cell proliferation have been typically assumed to be the main physical factors controlling tissue morphogenesis, recent experiments have revealed that spatial variations in the tissue physical (fluid/solid) state play a key role in shaping embryonic tissues. Here we theoretically study how the regional control of fluid and solid tissue states guides morphogenetic flows to shape the extending vertebrate body axis. Our results show that both the existence of a fluid-to-solid tissue transition along the anteroposterior axis and the tissue surface tension determine the shape of the tissue and its ability to elongate unidirectionally, with large tissue tensions preventing unidirectional elongation and promoting blob-like tissue expansions. We predict both the tissue morphogenetic flows and stresses that enable unidirectional axis elongation. Our results show the existence of a sharp transition in the structure of morphogenetic flows, from a flow with no vortices to a flow with two counter-rotating vortices, caused by a transition in the number and location of topological defects in the flow field. Finally, comparing the theoretical predictions to quantitative measurements of both tissue flows and shape during zebrafish body axis elongation, we show that the observed morphogenetic events can be explained by the existence of a fluid-to-solid tissue transition along the anteroposterior axis. These results highlight the role of spatiotemporally-controlled fluid-to-solid transitions in the tissue state as a physical mechanism of embryonic morphogenesis.

| S-EPMC8060277 | biostudies-literature

Rho-kinase directs Bazooka/Par-3 planar polarity during Drosophila axis elongation.

Project description:Cell rearrangements shape the Drosophila embryo via spatially regulated changes in cell shape and adhesion. We show that Bazooka/Par-3 (Baz) is required for the planar polarized distribution of myosin II and adherens junction proteins and polarized intercalary behavior is disrupted in baz mutants. The myosin II activator Rho-kinase is asymmetrically enriched at the anterior and posterior borders of intercalating cells in a pattern complementary to Baz. Loss of Rho-kinase results in expansion of the Baz domain, and activated Rho-kinase is sufficient to exclude Baz from the cortex. The planar polarized distribution of Baz requires its C-terminal domain. Rho-kinase can phosphorylate this domain and inhibit its interaction with phosphoinositide membrane lipids, suggesting a mechanism by which Rho-kinase could regulate Baz association with the cell cortex. These results demonstrate that Rho-kinase plays an instructive role in planar polarity by targeting Baz/Par-3 and myosin II to complementary cortical domains.

| S-EPMC3131216 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data