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No effect of attentional bias modification training in methamphetamine users receiving residential treatment.

ABSTRACT: RATIONALE:Attentional bias toward drug-related stimuli is a feature of drug addiction that is linked to craving and drug-seeking behavior. OBJECTIVES/METHOD:An attentional bias modification (ABM) program was tested in 42 methamphetamine-dependent clients (DSM-IV criteria) receiving residential treatment for their drug use. Participants were randomly assigned to one of two groups (N?=?21 each), receiving 12 sessions of either computerized ABM training (designed to train attention away from methamphetamine stimuli 100% of the time) or an attentional control condition (designed to train attention away from methamphetamine stimuli 50% of the time). Outcome measures included attentional bias to methamphetamine-related stimuli on a probe detection task, self-reported craving, and preferences to view methamphetamine-related images on a Simulated Drug Choice Task. A subset of participants (N?=?17) also underwent fMRI in a cue-induced craving paradigm. RESULTS:Poor split-half reliability was observed for the probe detection task. Using this task, attentional bias toward methamphetamine-related stimuli was greater after training than at baseline, irrespective of group (p?=?0.037). Spontaneous and cue-induced methamphetamine craving diminished with time (ps??0.05). ABM training did not influence selection of methamphetamine-related pictures in the Simulated Drug Choice task (p?>?0.05). In the fMRI assessment, cue-induced activation in the ventromedial prefrontal cortex was reduced over time, without an effect of ABM training. CONCLUSIONS:ABM training did not improve several clinically relevant variables in treatment-seeking methamphetamine users. Additional research is needed to improve the measurement of attentional bias.

SUBMITTER: Dean AC

PROVIDER: S-EPMC6415773 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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No effect of attentional bias modification training in methamphetamine users receiving residential treatment.

Dean Andy C AC Nurmi Erika L EL Moeller Scott J SJ Amir Nader N Rozenman Michelle M Ghahremani Dara G DG Johnson Maritza M Berberyan Robert R Hellemann Gerhard G Zhang Ziwei Z London Edythe D ED

Psychopharmacology 20181110 2

<h4>Rationale</h4>Attentional bias toward drug-related stimuli is a feature of drug addiction that is linked to craving and drug-seeking behavior.<h4>Objectives/method</h4>An attentional bias modification (ABM) program was tested in 42 methamphetamine-dependent clients (DSM-IV criteria) receiving residential treatment for their drug use. Participants were randomly assigned to one of two groups (N = 21 each), receiving 12 sessions of either computerized ABM training (designed to train attention a ...[more]

PMID: 30415277

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Project description:INTRODUCTION:Chronic musculoskeletal pain is a complex medical condition that can significantly impact quality of life. Patients with chronic pain demonstrate attentional biases towards pain-related information. The therapeutic benefits of modifying attentional biases by implicitly training attention away from pain-related information towards neutral information have been supported in a small number of published studies. Limited research however has explored the efficacy of modifying pain-related biases via the internet. This protocol describes a randomised, double-blind, internet-delivered attentional bias modification intervention, aimed to evaluate the efficacy of the intervention on reducing pain interference. Secondary outcomes are pain intensity, state and trait anxiety, depression, pain-related fear, and sleep impairment. This study will also explore the effects of training intensity on these outcomes, along with participants' perceptions about the therapy. METHODS AND ANALYSIS:The study is a double-blind, randomised controlled trial with four arms exploring the efficacy of online attentional bias modification training versus placebo training theorised to offer no specific therapeutic benefit. Participants with chronic musculoskeletal pain will be randomised to one of four groups: (1) 10-session attentional modification group; (2) 10-session placebo training group; (3) 18-session attentional modification group; or (4) 18-session placebo training group. In the attentional modification groups, the probe-classification version of the visual-probe task will be used to implicitly train attention away from threatening information towards neutral information. Following the intervention, participants will complete a short interview exploring their perceptions about the online training. In addition, a subgroup analysis for participants aged 16-24 and 25-60 will be undertaken. ETHICS AND DISSEMINATION:This study has been approved by the University of Southampton Research Ethics Committee. Results will be published in peer-reviewed journals, academic conferences, and in lay reports for pain charities and patient support groups. TRIAL REGISTRATION NUMBER:NCT02232100; Pre-results.

Dataset Information

No effect of attentional bias modification training in methamphetamine users receiving residential treatment.

Publications

No effect of attentional bias modification training in methamphetamine users receiving residential treatment.

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