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Tasmanian devils with contagious cancer exhibit a constricted T-cell repertoire diversity.


ABSTRACT: The Tasmanian devil (Sarcophilus harrisii) is threatened by a contagious cancer, known as Devil Facial Tumour Disease (DFTD). A highly diverse T-cell receptor (TCR) repertoire is crucial for successful host defence against cancers. By investigating TCR beta chain diversity in devils of different ages, we show that the T-cell repertoire in devils constricts in their second year of life, which may explain the higher DFTD prevalence in older devils. Unexpectedly, we also observed a pronounced decline in TCR diversity and T cell clonal expansion in devils after DFTD infection. These findings overturned the previous assumption that DFTD did not directly impact host immunity.

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC6416256 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Tasmanian devils with contagious cancer exhibit a constricted T-cell repertoire diversity.

Cheng Yuanyuan Y   Makara Mariano M   Peel Emma E   Fox Samantha S   Papenfuss Anthony T AT   Belov Katherine K  

Communications biology 20190313


The Tasmanian devil (<i>Sarcophilus harrisii</i>) is threatened by a contagious cancer, known as Devil Facial Tumour Disease (DFTD). A highly diverse T-cell receptor (TCR) repertoire is crucial for successful host defence against cancers. By investigating TCR beta chain diversity in devils of different ages, we show that the T-cell repertoire in devils constricts in their second year of life, which may explain the higher DFTD prevalence in older devils. Unexpectedly, we also observed a pronounce  ...[more]

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