Ontology highlight
ABSTRACT:
SUBMITTER: Cheng Y
PROVIDER: S-EPMC6416256 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Cheng Yuanyuan Y Makara Mariano M Peel Emma E Fox Samantha S Papenfuss Anthony T AT Belov Katherine K
Communications biology 20190313
The Tasmanian devil (<i>Sarcophilus harrisii</i>) is threatened by a contagious cancer, known as Devil Facial Tumour Disease (DFTD). A highly diverse T-cell receptor (TCR) repertoire is crucial for successful host defence against cancers. By investigating TCR beta chain diversity in devils of different ages, we show that the T-cell repertoire in devils constricts in their second year of life, which may explain the higher DFTD prevalence in older devils. Unexpectedly, we also observed a pronounce ...[more]