Ontology highlight
ABSTRACT:
SUBMITTER: van der Poel M
PROVIDER: S-EPMC6416318 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Nature communications 20190313 1
Here we report the transcriptional profile of human microglia, isolated from normal-appearing grey matter (GM) and white matter (WM) of multiple sclerosis (MS) and non-neurological control donors, to find possible early changes related to MS pathology. Microglia show a clear region-specific profile, indicated by higher expression of type-I interferon genes in GM and higher expression of NF-κB pathway genes in WM. Transcriptional changes in MS microglia also differ between GM and WM. MS WM microg ...[more]