Phage single-gene lysis: Finding the weak spot in the bacterial cell wall.
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ABSTRACT:
SUBMITTER: Chamakura K
PROVIDER: S-EPMC6416421 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Phage single-gene lysis: Finding the weak spot in the bacterial cell wall.
Chamakura Karthik K Young Ry R
The Journal of biological chemistry 20181112 10
In general, the last step in the vegetative cycle of bacterial viruses, or bacteriophages, is lysis of the host. dsDNA phages require multiple lysis proteins, including at least one enzyme that degrades the cell wall (peptidoglycan (PG)). In contrast, the lytic ssDNA and ssRNA phages have a single lysis protein that achieves cell lysis without enzymatically degrading the PG. Here, we review four "single-gene lysis" or Sgl proteins. Three of the Sgls block bacterial cell wall synthesis by binding ...[more]
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