Urinary concentrations of phthalate biomarkers and weight change among postmenopausal women: a prospective cohort study.

ABSTRACT:

Background

Some phthalates are endocrine disrupting chemicals used as plasticizers in consumer products, and have been associated with obesity in cross-sectional studies, yet prospective evaluations of weight change are lacking. Our objective was to evaluate associations between phthalate biomarker concentrations and weight and weight change among postmenopausal women.

Methods

We performed cross-sectional (N = 997) and longitudinal analyses (N = 660) among postmenopausal Women's Health Initiative participants. We measured 13 phthalate metabolites and creatinine in spot urine samples provided at baseline. Participants' weight and height measured at in-person clinic visits at baseline, year 3, and year 6 were used to calculate body mass index (BMI). We fit multivariable multin

SUBMITTER: Diaz Santana MV 

PROVIDER: S-EPMC6417117 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature