Ontology highlight
ABSTRACT: Background
Some phthalates are endocrine disrupting chemicals used as plasticizers in consumer products, and have been associated with obesity in cross-sectional studies, yet prospective evaluations of weight change are lacking. Our objective was to evaluate associations between phthalate biomarker concentrations and weight and weight change among postmenopausal women.Methods
We performed cross-sectional (N = 997) and longitudinal analyses (N = 660) among postmenopausal Women's Health Initiative participants. We measured 13 phthalate metabolites and creatinine in spot urine samples provided at baseline. Participants' weight and height measured at in-person clinic visits at baseline, year 3, and year 6 were used to calculate body mass index (BMI). We fit multivariable multinomial logistic regression models to explore cross-sectional associations between each phthalate biomarker and baseline BMI category. We evaluated longitudinal associations between each biomarker and weight change using mixed effects linear regression models.Results
In cross-sectional analyses, urinary concentrations of some biomarkers were positively associated with obesity prevalence (e.g. sum of di (2-ethylhexyl) phthalate metabolites [ΣDEHP] 4th vs 1st quartile OR = 3.29, 95% CI 1.80-6.03 [p trend< 0.001] vs normal). In longitudinal analyses, positive trends with weight gain between baseline and year 3 were observed for mono-(2-ethyl-5-oxohexyl) phthalate, monoethyl phthalate (MEP), mono-hydroxybutyl phthalate, and mono-hydroxyisobutyl phthalate (e.g. + 2.32 kg [95% CI 0.93-3.72] for 4th vs 1st quartile of MEP; p trend < 0.001). No statistically significant associations were observed between biomarkers and weight gain over 6 years.Conclusions
Certain phthalates may contribute to short-term weight gain among postmenopausal women.
SUBMITTER: Diaz Santana MV
PROVIDER: S-EPMC6417117 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Díaz Santana Mary V MV Hankinson Susan E SE Bigelow Carol C Sturgeon Susan R SR Zoeller R Thomas RT Tinker Lesley L Manson Jo Ann E JAE Calafat Antonia M AM Meliker Jaymie R JR Reeves Katherine W KW
Environmental health : a global access science source 20190312 1
<h4>Background</h4>Some phthalates are endocrine disrupting chemicals used as plasticizers in consumer products, and have been associated with obesity in cross-sectional studies, yet prospective evaluations of weight change are lacking. Our objective was to evaluate associations between phthalate biomarker concentrations and weight and weight change among postmenopausal women.<h4>Methods</h4>We performed cross-sectional (N = 997) and longitudinal analyses (N = 660) among postmenopausal Women's H ...[more]