New insights on unspecific peroxygenases: superfamily reclassification and evolution.

ABSTRACT:

Background

Unspecific peroxygenases (UPO) (EC 1.11.2.1) represent an intriguing oxidoreductase sub-subclass of heme proteins with peroxygenase and peroxidase activity. With over 300 identified substrates, UPOs catalyze numerous oxidations including 1- or 2- electron oxygenation, selective oxyfunctionalizations, which make them most significant in organic syntheses and potentially attractive as industrial biocatalysts. There are very few UPOs available with distinct properties, notably, MroUPO which shows behavior ranging between UPO and another heme-thiolate peroxidase, called Chloroperoxidase (CPO). It prompted us to search for more UPOs in fungal kingdom which led us to studying their relationship with CPO.

Results

In this study, we searched for novel UPOs in more than 800

SUBMITTER: Faiza M 

PROVIDER: S-EPMC6417270 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature