Ontology highlight
ABSTRACT:
SUBMITTER: Laing AG
PROVIDER: S-EPMC6417714 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Laing Adam G AG Fanelli Giorgia G Ramirez-Valdez Andrei A Lechler Robert I RI Lombardi Giovanna G Sharpe Paul T PT
PloS one 20190314 3
The physiological role of mesenchymal stem cells (MSCs) is to provide a source of cells to replace mesenchymal-derivatives in stromal tissues with high cell turnover or following stromal tissue damage to elicit repair. Human MSCs have been shown to suppress in vitro T-cell responses via a number of mechanisms including indoleamine 2,3-dioxygenase (IDO). This immunomodulatory capacity is likely to be related to their in vivo function in tissue repair where local, transient suppression of immune r ...[more]