Ontology highlight
ABSTRACT:
SUBMITTER: Manhart A
PROVIDER: S-EPMC6417862 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
eLife 20190314
Principles of regulation of actin network dimensions are fundamentally important for cell functions, yet remain unclear. Using both in vitro and in silico approaches, we studied the effect of key parameters, such as actin density, ADF/Cofilin concentration and network width on the network length. In the presence of ADF/Cofilin, networks reached equilibrium and became treadmilling. At the trailing edge, the network disintegrated into large fragments. A mathematical model predicts the network leng ...[more]