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Telmisartan attenuates kidney apoptosis and autophagy-related protein expression levels in an intermittent hypoxia mouse model.


ABSTRACT: PURPOSE:Obstructive sleep apnea (OSA) is associated with renal impairs. As a novel pathophysiological hallmark of OSA, chronic intermittent hypoxia (CIH) enhances apoptosis and autophagy. The present study aims to evaluate the effect of telmisartan on CIH-induced kidney apoptosis and autophagy in a mouse model of OSA. MATERIALS AND METHODS:Mice were randomly allocated to normoxia, CIH, and CIH+telmisartan groups (n =?12 in each group). The CIH exposure duration was 12 weeks. Mice in the CIH+telmisartan group received telmisartan administration. The terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay and western blotting of Bax and cleaved caspase-3 were conducted for evaluating apoptosis in kidney tissue. While the autophagy-related proteins, beclin-1 and LC3, were also observed via western blotting. RESULTS:The percentage of apoptotic cell in the CIH group was significantly higher than that of normoxia group; meanwhile, Bax and cleaved caspase-3 protein levels were increased in the CIH group than those of normoxia group (all p 

SUBMITTER: Zhang XB 

PROVIDER: S-EPMC6418059 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Telmisartan attenuates kidney apoptosis and autophagy-related protein expression levels in an intermittent hypoxia mouse model.

Zhang Xiao-Bin XB   Cai Jing-Huang JH   Yang Yu-Yun YY   Zeng Yi-Ming YM   Zeng Hui-Qing HQ   Wang Miao M   Cheng Xiao X   Luo Xiongbiao X   Ewurum Henry Chidozie HC  

Sleep & breathing = Schlaf & Atmung 20180915 1


<h4>Purpose</h4>Obstructive sleep apnea (OSA) is associated with renal impairs. As a novel pathophysiological hallmark of OSA, chronic intermittent hypoxia (CIH) enhances apoptosis and autophagy. The present study aims to evaluate the effect of telmisartan on CIH-induced kidney apoptosis and autophagy in a mouse model of OSA.<h4>Materials and methods</h4>Mice were randomly allocated to normoxia, CIH, and CIH+telmisartan groups (n = 12 in each group). The CIH exposure duration was 12 weeks. Mice  ...[more]

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