Ontology highlight
ABSTRACT:
SUBMITTER: Zhang XB
PROVIDER: S-EPMC6418059 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Zhang Xiao-Bin XB Cai Jing-Huang JH Yang Yu-Yun YY Zeng Yi-Ming YM Zeng Hui-Qing HQ Wang Miao M Cheng Xiao X Luo Xiongbiao X Ewurum Henry Chidozie HC
Sleep & breathing = Schlaf & Atmung 20180915 1
<h4>Purpose</h4>Obstructive sleep apnea (OSA) is associated with renal impairs. As a novel pathophysiological hallmark of OSA, chronic intermittent hypoxia (CIH) enhances apoptosis and autophagy. The present study aims to evaluate the effect of telmisartan on CIH-induced kidney apoptosis and autophagy in a mouse model of OSA.<h4>Materials and methods</h4>Mice were randomly allocated to normoxia, CIH, and CIH+telmisartan groups (n = 12 in each group). The CIH exposure duration was 12 weeks. Mice ...[more]