Ontology highlight
ABSTRACT:
SUBMITTER: Anamthathmakula P
PROVIDER: S-EPMC6418149 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Anamthathmakula Prashanth P Miryala Chandra Suma Johnson CSJ Moreci Rebecca S RS Kyathanahalli Chandrashekara C Hassan Sonia S SS Condon Jennifer C JC Jeyasuria Pancharatnam P
Scientific reports 20190314 1
The elevated level of Steroidogenic Factor 1 (Nr5a1, Sf-1) expression in the male gonadal development pathway, post sex determination, implies a vital role in testis gonadal differentiation. In this study we generated Sertoli cell-specific Nr5a1 KO mice (SC-SF-1<sup>-/-</sup>) at E14.5, which coincides with testis development post sex determination, using the Amh-Cre mouse model. Analysis of SC-SF-1<sup>-/-</sup> (Sertoli cell specific Nr5a1 knockout) testes demonstrated apoptosis as early as E1 ...[more]