Dataset Information

Regional GABA Concentrations Modulate Inter-network Resting-state Functional Connectivity.

ABSTRACT: Coordinated activity within and differential activity between large-scale neuronal networks such as the default mode network (DMN) and the control network (CN) is a critical feature of brain organization. The CN usually exhibits activations in response to cognitive tasks while the DMN shows deactivations; in addition, activity between the two networks is anti-correlated at rest. To address this issue, we used functional MRI to measure whole-brain BOLD signal during resting-state and task-evoked conditions, and MR spectroscopy (MRS) to quantify GABA and glutamate concentrations, in nodes within the DMN and CN (MPFC and DLPFC, respectively) in 19 healthy individuals at 3 Tesla. We found that GABA concentrations in the MPFC were significantly associated with DMN deactivation during a working memory task and with anti-correlation between DMN and CN at rest and during task performance, while GABA concentrations in the DLPFC weakly modulated DMN-CN anti-correlation in the opposite direction. Highlighting specificity, glutamate played a less significant role related to brain activity. These findings indicate that GABA in the MPFC is potentially involved in orchestrating between-network brain activity at rest and during task performance.

SUBMITTER: Chen X

PROVIDER: S-EPMC6418388 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Regional GABA Concentrations Modulate Inter-network Resting-state Functional Connectivity.

Chen Xi X Fan Xiaoying X Hu Yuzheng Y Zuo Chun C Whitfield-Gabrieli Susan S Holt Daphne D Gong Qiyong Q Yang Yihong Y Pizzagalli Diego A DA Du Fei F Ongur Dost D

Cerebral cortex (New York, N.Y. : 1991) 20190401 4

Coordinated activity within and differential activity between large-scale neuronal networks such as the default mode network (DMN) and the control network (CN) is a critical feature of brain organization. The CN usually exhibits activations in response to cognitive tasks while the DMN shows deactivations; in addition, activity between the two networks is anti-correlated at rest. To address this issue, we used functional MRI to measure whole-brain BOLD signal during resting-state and task-evoked ...[more]

PMID: 29608677

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Dataset Information

Regional GABA Concentrations Modulate Inter-network Resting-state Functional Connectivity.

Publications

Regional GABA Concentrations Modulate Inter-network Resting-state Functional Connectivity.

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