Ontology highlight
ABSTRACT:
SUBMITTER: Davies AJ
PROVIDER: S-EPMC6418410 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Cell 20190131 4
Sensory axons degenerate following separation from their cell body, but partial injury to peripheral nerves may leave the integrity of damaged axons preserved. We show that an endogenous ligand for the natural killer (NK) cell receptor NKG2D, Retinoic Acid Early 1 (RAE1), is re-expressed in adult dorsal root ganglion neurons following peripheral nerve injury, triggering selective degeneration of injured axons. Infiltration of cytotoxic NK cells into the sciatic nerve by extravasation occurs with ...[more]