Ontology highlight
ABSTRACT:
SUBMITTER: Kinsella FAM
PROVIDER: S-EPMC6418492 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Kinsella Francesca A M FAM Zuo Jianmin J Inman Charlotte F CF Pearce Hayden H Maggs Luke L Eldershaw Suzy E SE Chan Y L Tracey YLT Chan Y L Tracey YLT Nunnick Jane J Nagra Sandeep S Griffiths Mike M Craddock Charles C Malladi Ram R Moss Paul P
Blood advances 20190301 5
Transplantation is an effective treatment of many clinical disorders, but the mechanisms that regulate immunological tolerance are uncertain and remain central to improving patient outcome. Hemopoietic stem cell transplantation (SCT) often establishes "mixed chimerism" in which immune cells from both the donor and patient coexist in vivo in a setting of immunological tolerance. We studied immune function in 69 patients within 2 months following SCT; 37 were fully donor and 32 displayed mixed chi ...[more]