Ontology highlight
ABSTRACT:
SUBMITTER: Shao TY
PROVIDER: S-EPMC6419754 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Shao Tzu-Yu TY Ang W X Gladys WXG Jiang Tony T TT Huang Felicia Scaggs FS Andersen Heidi H Kinder Jeremy M JM Pham Giang G Burg Ashley R AR Ruff Brandy B Gonzalez Tammy T Khurana Hershey Gurjit K GK Haslam David B DB Way Sing Sing SS
Cell host & microbe 20190301 3
Mucosal barriers are densely colonized by pathobiont microbes such as Candida albicans, capable of invasive disseminated infection. However, systemic infections occur infrequently in healthy individuals, suggesting that pathobiont commensalism may elicit host benefits. We show that intestinal colonization with C. albicans drives systemic expansion of fungal-specific Th17 CD4<sup>+</sup> T cells and IL-17 responsiveness by circulating neutrophils, which synergistically protect against C. albicans ...[more]